Final results of a phase 3 study of trebananib plus weekly paclitaxel in recurrent ovarian cancer (TRINOVA-1): Long-term survival, impact of ascites, and progression-free survival-2.
Identifieur interne : 001E91 ( Main/Exploration ); précédent : 001E90; suivant : 001E92Final results of a phase 3 study of trebananib plus weekly paclitaxel in recurrent ovarian cancer (TRINOVA-1): Long-term survival, impact of ascites, and progression-free survival-2.
Auteurs : Bradley J. Monk [États-Unis] ; Andrés Poveda [Espagne] ; Ignace Vergote [Belgique] ; Francesco Raspagliesi [Italie] ; Keiichi Fujiwara [Japon] ; Duk-Soo Bae [Corée du Sud] ; Ana Oaknin [Espagne] ; Isabelle Ray-Coquard [France] ; Diane M. Provencher [Canada] ; Beth Y. Karlan [États-Unis] ; Catherine Lhommé [France] ; Gary Richardson [Australie] ; Dolores Gallardo Rinc N [Mexique] ; Robert L. Coleman [États-Unis] ; Christian Marth [Autriche] ; Arija Brize [Lettonie] ; Michel Fabbro [France] ; Andrés Redondo [Espagne] ; Aristotelis Bamias [Grèce] ; Haijun Ma [États-Unis] ; Florian D. Vogl [États-Unis] ; Bruce A. Bach [États-Unis] ; Amit M. Oza [Canada]Source :
- Gynecologic oncology [ 1095-6859 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Ascites (étiologie), Femelle, Humains, Méthode en double aveugle, Paclitaxel (administration et posologie), Paclitaxel (effets indésirables), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Protéines de fusion recombinantes (administration et posologie), Protéines de fusion recombinantes (effets indésirables), Récidive tumorale locale (mortalité), Récidive tumorale locale (traitement médicamenteux), Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs de l'ovaire (), Tumeurs de l'ovaire (mortalité), Tumeurs de l'ovaire (traitement médicamenteux).
- MESH :
- administration et posologie : Paclitaxel, Protéines de fusion recombinantes.
- effets indésirables : Paclitaxel, Protéines de fusion recombinantes.
- mortalité : Récidive tumorale locale, Tumeurs de l'ovaire.
- traitement médicamenteux : Récidive tumorale locale, Tumeurs de l'ovaire.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- étiologie : Ascites.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Méthode en double aveugle, Sujet âgé, Sujet âgé de 80 ans ou plus, Survie sans rechute, Tumeurs de l'ovaire.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Ascites (etiology), Disease-Free Survival, Double-Blind Method, Female, Humans, Middle Aged, Neoplasm Recurrence, Local (drug therapy), Neoplasm Recurrence, Local (mortality), Ovarian Neoplasms (complications), Ovarian Neoplasms (drug therapy), Ovarian Neoplasms (mortality), Paclitaxel (administration & dosage), Paclitaxel (adverse effects), Recombinant Fusion Proteins (administration & dosage), Recombinant Fusion Proteins (adverse effects).
- MESH :
- chemical , administration & dosage : Paclitaxel, Recombinant Fusion Proteins.
- chemical , adverse effects : Paclitaxel, Recombinant Fusion Proteins.
- complications : Ovarian Neoplasms.
- drug therapy : Neoplasm Recurrence, Local, Ovarian Neoplasms.
- etiology : Ascites.
- mortality : Neoplasm Recurrence, Local, Ovarian Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Adult, Aged, Aged, 80 and over, Disease-Free Survival, Double-Blind Method, Female, Humans, Middle Aged.
Abstract
Trebananib, a peptibody that blocks binding of angiopoietin-1 and -2 to Tie2, significantly prolonged progression-free survival (PFS) in patients with recurrent epithelial ovarian cancer in the phase 3 TRINOVA-1 study. We report overall survival (OS) in the intent-to-treat population and clinically relevant subgroups and time to second disease progression (PFS-2).
DOI: 10.1016/j.ygyno.2016.07.112
PubMed: 27546885
Affiliations:
- Australie, Autriche, Belgique, Canada, Corée du Sud, Espagne, France, Grèce, Italie, Japon, Lettonie, Mexique, États-Unis
- Arizona, Attique (région), Auvergne-Rhône-Alpes, Californie, Catalogne, Communauté de Madrid, Languedoc-Roussillon, Occitanie (région administrative), Ontario, Rhône-Alpes, Région capitale de Séoul, Texas
- Athènes, Barcelone, Lyon, Madrid, Montpellier, Séoul, Toronto
- Université de Toronto
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Le document en format XML
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Provencher</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gynecologic Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Gynecologic Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation wicri:level="2"><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lhomme, Catherine" sort="Lhomme, Catherine" uniqKey="Lhomme C" first="Catherine" last="Lhommé">Catherine Lhommé</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Institut Gustave Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, Gary" sort="Richardson, Gary" uniqKey="Richardson G" first="Gary" last="Richardson">Gary Richardson</name><affiliation wicri:level="1"><nlm:affiliation>Academic Haematology and Oncology, Cabrini Hospital, Malvern, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Haematology and Oncology, Cabrini Hospital, Malvern, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Rinc N, Dolores Gallardo" sort="Rinc N, Dolores Gallardo" uniqKey="Rinc N D" first="Dolores Gallardo" last="Rinc N">Dolores Gallardo Rinc N</name><affiliation wicri:level="1"><nlm:affiliation>Subdirección de Medicina Interna, Instituto Nacional de Cancerologia, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Subdirección de Medicina Interna, Instituto Nacional de Cancerologia, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Marth, Christian" sort="Marth, Christian" uniqKey="Marth C" first="Christian" last="Marth">Christian Marth</name><affiliation wicri:level="1"><nlm:affiliation>Universitätsklinik für Gynäkologie und Geburtshilfe, Medizinische Universität Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Universitätsklinik für Gynäkologie und Geburtshilfe, Medizinische Universität Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Brize, Arija" sort="Brize, Arija" uniqKey="Brize A" first="Arija" last="Brize">Arija Brize</name><affiliation wicri:level="1"><nlm:affiliation>Latvian Oncology Center, Riga Eastern Clinical University Hospital, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian Oncology Center, Riga Eastern Clinical University Hospital, Riga</wicri:regionArea><wicri:noRegion>Riga</wicri:noRegion></affiliation></author><author><name sortKey="Fabbro, Michel" sort="Fabbro, Michel" uniqKey="Fabbro M" first="Michel" last="Fabbro">Michel Fabbro</name><affiliation wicri:level="3"><nlm:affiliation>Regional Cancer Institute Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Regional Cancer Institute Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Redondo, Andres" sort="Redondo, Andres" uniqKey="Redondo A" first="Andrés" last="Redondo">Andrés Redondo</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Universitario La Paz Idi-Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario La Paz Idi-Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bamias, Aristotelis" sort="Bamias, Aristotelis" uniqKey="Bamias A" first="Aristotelis" last="Bamias">Aristotelis Bamias</name><affiliation wicri:level="3"><nlm:affiliation>Alexandra Hospital, Department of Clinical Therapeutics, National & Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Alexandra Hospital, Department of Clinical Therapeutics, National & Kapodistrian University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Ma, Haijun" sort="Ma, Haijun" uniqKey="Ma H" first="Haijun" last="Ma">Haijun Ma</name><affiliation wicri:level="2"><nlm:affiliation>Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vogl, Florian D" sort="Vogl, Florian D" uniqKey="Vogl F" first="Florian D" last="Vogl">Florian D. Vogl</name><affiliation wicri:level="2"><nlm:affiliation>Global Development Oncology, Amgen Inc., Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Development Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bach, Bruce A" sort="Bach, Bruce A" uniqKey="Bach B" first="Bruce A" last="Bach">Bruce A. Bach</name><affiliation wicri:level="2"><nlm:affiliation>Global Development Oncology, Amgen Inc., Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Development Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Oza, Amit M" sort="Oza, Amit M" uniqKey="Oza A" first="Amit M" last="Oza">Amit M. Oza</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Princess Margaret Hospital, University of Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Princess Margaret Hospital, University of Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27546885</idno><idno type="pmid">27546885</idno><idno type="doi">10.1016/j.ygyno.2016.07.112</idno><idno type="wicri:Area/PubMed/Corpus">001826</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001826</idno><idno type="wicri:Area/PubMed/Curation">001803</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001803</idno><idno type="wicri:Area/PubMed/Checkpoint">001803</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001803</idno><idno type="wicri:Area/Ncbi/Merge">003A15</idno><idno type="wicri:Area/Ncbi/Curation">003A15</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A15</idno><idno type="wicri:Area/Main/Merge">001E90</idno><idno type="wicri:Area/Main/Curation">001E91</idno><idno type="wicri:Area/Main/Exploration">001E91</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Final results of a phase 3 study of trebananib plus weekly paclitaxel in recurrent ovarian cancer (TRINOVA-1): Long-term survival, impact of ascites, and progression-free survival-2.</title><author><name sortKey="Monk, Bradley J" sort="Monk, Bradley J" uniqKey="Monk B" first="Bradley J" last="Monk">Bradley J. Monk</name><affiliation wicri:level="2"><nlm:affiliation>Department of Obstetrics and Gynecology, University of Arizona Cancer Center at Dignity Health St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA. Electronic address: bradley.monk@chw.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Obstetrics and Gynecology, University of Arizona Cancer Center at Dignity Health St. Joseph's Hospital and Medical Center, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Poveda, Andres" sort="Poveda, Andres" uniqKey="Poveda A" first="Andrés" last="Poveda">Andrés Poveda</name><affiliation wicri:level="1"><nlm:affiliation>Area Clinica de Oncologia Ginecológica, Fundación Instituto Valenciano de Oncología, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Area Clinica de Oncologia Ginecológica, Fundación Instituto Valenciano de Oncología, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Vergote, Ignace" sort="Vergote, Ignace" uniqKey="Vergote I" first="Ignace" last="Vergote">Ignace Vergote</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynecology, University Hospital Leuven, Leuven Cancer Institute, KU Leuven, European Union, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Obstetrics and Gynecology, University Hospital Leuven, Leuven Cancer Institute, KU Leuven, European Union</wicri:regionArea><wicri:noRegion>European Union</wicri:noRegion></affiliation></author><author><name sortKey="Raspagliesi, Francesco" sort="Raspagliesi, Francesco" uniqKey="Raspagliesi F" first="Francesco" last="Raspagliesi">Francesco Raspagliesi</name><affiliation wicri:level="1"><nlm:affiliation>Gynecologic Oncology Unit, Fondazione IRCCS, Istituto Nazionale per la Cura e lo Studio dei Tumori, Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Gynecologic Oncology Unit, Fondazione IRCCS, Istituto Nazionale per la Cura e lo Studio dei Tumori, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Fujiwara, Keiichi" sort="Fujiwara, Keiichi" uniqKey="Fujiwara K" first="Keiichi" last="Fujiwara">Keiichi Fujiwara</name><affiliation wicri:level="1"><nlm:affiliation>Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka-Shi, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka-Shi</wicri:regionArea><wicri:noRegion>Hidaka-Shi</wicri:noRegion></affiliation></author><author><name sortKey="Bae, Duk Soo" sort="Bae, Duk Soo" uniqKey="Bae D" first="Duk-Soo" last="Bae">Duk-Soo Bae</name><affiliation wicri:level="3"><nlm:affiliation>Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Oaknin, Ana" sort="Oaknin, Ana" uniqKey="Oaknin A" first="Ana" last="Oaknin">Ana Oaknin</name><affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name><affiliation wicri:level="3"><nlm:affiliation>Université Lyon-I, Centre Léon Bérard, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Lyon-I, Centre Léon Bérard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Provencher, Diane M" sort="Provencher, Diane M" uniqKey="Provencher D" first="Diane M" last="Provencher">Diane M. Provencher</name><affiliation wicri:level="1"><nlm:affiliation>Division of Gynecologic Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Gynecologic Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><affiliation wicri:level="2"><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lhomme, Catherine" sort="Lhomme, Catherine" uniqKey="Lhomme C" first="Catherine" last="Lhommé">Catherine Lhommé</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Institut Gustave Roussy, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine, Institut Gustave Roussy, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Richardson, Gary" sort="Richardson, Gary" uniqKey="Richardson G" first="Gary" last="Richardson">Gary Richardson</name><affiliation wicri:level="1"><nlm:affiliation>Academic Haematology and Oncology, Cabrini Hospital, Malvern, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Academic Haematology and Oncology, Cabrini Hospital, Malvern, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Rinc N, Dolores Gallardo" sort="Rinc N, Dolores Gallardo" uniqKey="Rinc N D" first="Dolores Gallardo" last="Rinc N">Dolores Gallardo Rinc N</name><affiliation wicri:level="1"><nlm:affiliation>Subdirección de Medicina Interna, Instituto Nacional de Cancerologia, Mexico City, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Subdirección de Medicina Interna, Instituto Nacional de Cancerologia, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Marth, Christian" sort="Marth, Christian" uniqKey="Marth C" first="Christian" last="Marth">Christian Marth</name><affiliation wicri:level="1"><nlm:affiliation>Universitätsklinik für Gynäkologie und Geburtshilfe, Medizinische Universität Innsbruck, Innsbruck, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Universitätsklinik für Gynäkologie und Geburtshilfe, Medizinische Universität Innsbruck, Innsbruck</wicri:regionArea><wicri:noRegion>Innsbruck</wicri:noRegion></affiliation></author><author><name sortKey="Brize, Arija" sort="Brize, Arija" uniqKey="Brize A" first="Arija" last="Brize">Arija Brize</name><affiliation wicri:level="1"><nlm:affiliation>Latvian Oncology Center, Riga Eastern Clinical University Hospital, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian Oncology Center, Riga Eastern Clinical University Hospital, Riga</wicri:regionArea><wicri:noRegion>Riga</wicri:noRegion></affiliation></author><author><name sortKey="Fabbro, Michel" sort="Fabbro, Michel" uniqKey="Fabbro M" first="Michel" last="Fabbro">Michel Fabbro</name><affiliation wicri:level="3"><nlm:affiliation>Regional Cancer Institute Montpellier, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Regional Cancer Institute Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Redondo, Andres" sort="Redondo, Andres" uniqKey="Redondo A" first="Andrés" last="Redondo">Andrés Redondo</name><affiliation wicri:level="3"><nlm:affiliation>Hospital Universitario La Paz Idi-Paz, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Universitario La Paz Idi-Paz, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Bamias, Aristotelis" sort="Bamias, Aristotelis" uniqKey="Bamias A" first="Aristotelis" last="Bamias">Aristotelis Bamias</name><affiliation wicri:level="3"><nlm:affiliation>Alexandra Hospital, Department of Clinical Therapeutics, National & Kapodistrian University of Athens, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Alexandra Hospital, Department of Clinical Therapeutics, National & Kapodistrian University of Athens, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Ma, Haijun" sort="Ma, Haijun" uniqKey="Ma H" first="Haijun" last="Ma">Haijun Ma</name><affiliation wicri:level="2"><nlm:affiliation>Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vogl, Florian D" sort="Vogl, Florian D" uniqKey="Vogl F" first="Florian D" last="Vogl">Florian D. Vogl</name><affiliation wicri:level="2"><nlm:affiliation>Global Development Oncology, Amgen Inc., Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Development Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Bach, Bruce A" sort="Bach, Bruce A" uniqKey="Bach B" first="Bruce A" last="Bach">Bruce A. Bach</name><affiliation wicri:level="2"><nlm:affiliation>Global Development Oncology, Amgen Inc., Thousand Oaks, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Global Development Oncology, Amgen Inc., Thousand Oaks, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Oza, Amit M" sort="Oza, Amit M" uniqKey="Oza A" first="Amit M" last="Oza">Amit M. Oza</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Princess Margaret Hospital, University of Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Princess Margaret Hospital, University of Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Gynecologic oncology</title><idno type="eISSN">1095-6859</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antineoplastic Combined Chemotherapy Protocols (therapeutic use)</term><term>Ascites (etiology)</term><term>Disease-Free Survival</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Neoplasm Recurrence, Local (drug therapy)</term><term>Neoplasm Recurrence, Local (mortality)</term><term>Ovarian Neoplasms (complications)</term><term>Ovarian Neoplasms (drug therapy)</term><term>Ovarian Neoplasms (mortality)</term><term>Paclitaxel (administration & dosage)</term><term>Paclitaxel (adverse effects)</term><term>Recombinant Fusion Proteins (administration & dosage)</term><term>Recombinant Fusion Proteins (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Ascites (étiologie)</term><term>Femelle</term><term>Humains</term><term>Méthode en double aveugle</term><term>Paclitaxel (administration et posologie)</term><term>Paclitaxel (effets indésirables)</term><term>Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique)</term><term>Protéines de fusion recombinantes (administration et posologie)</term><term>Protéines de fusion recombinantes (effets indésirables)</term><term>Récidive tumorale locale (mortalité)</term><term>Récidive tumorale locale (traitement médicamenteux)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tumeurs de l'ovaire ()</term><term>Tumeurs de l'ovaire (mortalité)</term><term>Tumeurs de l'ovaire (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Paclitaxel</term><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Paclitaxel</term><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Paclitaxel</term><term>Protéines de fusion recombinantes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Neoplasm Recurrence, Local</term><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Paclitaxel</term><term>Protéines de fusion recombinantes</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Ascites</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Neoplasm Recurrence, Local</term><term>Ovarian Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Récidive tumorale locale</term><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Combined Chemotherapy Protocols</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Récidive tumorale locale</term><term>Tumeurs de l'ovaire</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Protocoles de polychimiothérapie antinéoplasique</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Ascites</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease-Free Survival</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Méthode en double aveugle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Survie sans rechute</term><term>Tumeurs de l'ovaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Trebananib, a peptibody that blocks binding of angiopoietin-1 and -2 to Tie2, significantly prolonged progression-free survival (PFS) in patients with recurrent epithelial ovarian cancer in the phase 3 TRINOVA-1 study. We report overall survival (OS) in the intent-to-treat population and clinically relevant subgroups and time to second disease progression (PFS-2).</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Japon</li><li>Lettonie</li><li>Mexique</li><li>États-Unis</li></country><region><li>Arizona</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Ontario</li><li>Rhône-Alpes</li><li>Région capitale de Séoul</li><li>Texas</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Lyon</li><li>Madrid</li><li>Montpellier</li><li>Séoul</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Arizona"><name sortKey="Monk, Bradley J" sort="Monk, Bradley J" uniqKey="Monk B" first="Bradley J" last="Monk">Bradley J. Monk</name></region><name sortKey="Bach, Bruce A" sort="Bach, Bruce A" uniqKey="Bach B" first="Bruce A" last="Bach">Bruce A. Bach</name><name sortKey="Coleman, Robert L" sort="Coleman, Robert L" uniqKey="Coleman R" first="Robert L" last="Coleman">Robert L. Coleman</name><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name><name sortKey="Ma, Haijun" sort="Ma, Haijun" uniqKey="Ma H" first="Haijun" last="Ma">Haijun Ma</name><name sortKey="Vogl, Florian D" sort="Vogl, Florian D" uniqKey="Vogl F" first="Florian D" last="Vogl">Florian D. Vogl</name></country><country name="Espagne"><noRegion><name sortKey="Poveda, Andres" sort="Poveda, Andres" uniqKey="Poveda A" first="Andrés" last="Poveda">Andrés Poveda</name></noRegion><name sortKey="Oaknin, Ana" sort="Oaknin, Ana" uniqKey="Oaknin A" first="Ana" last="Oaknin">Ana Oaknin</name><name sortKey="Redondo, Andres" sort="Redondo, Andres" uniqKey="Redondo A" first="Andrés" last="Redondo">Andrés Redondo</name></country><country name="Belgique"><noRegion><name sortKey="Vergote, Ignace" sort="Vergote, Ignace" uniqKey="Vergote I" first="Ignace" last="Vergote">Ignace Vergote</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Raspagliesi, Francesco" sort="Raspagliesi, Francesco" uniqKey="Raspagliesi F" first="Francesco" last="Raspagliesi">Francesco Raspagliesi</name></noRegion></country><country name="Japon"><noRegion><name sortKey="Fujiwara, Keiichi" sort="Fujiwara, Keiichi" uniqKey="Fujiwara K" first="Keiichi" last="Fujiwara">Keiichi Fujiwara</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Bae, Duk Soo" sort="Bae, Duk Soo" uniqKey="Bae D" first="Duk-Soo" last="Bae">Duk-Soo Bae</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Ray Coquard, Isabelle" sort="Ray Coquard, Isabelle" uniqKey="Ray Coquard I" first="Isabelle" last="Ray-Coquard">Isabelle Ray-Coquard</name></region><name sortKey="Fabbro, Michel" sort="Fabbro, Michel" uniqKey="Fabbro M" first="Michel" last="Fabbro">Michel Fabbro</name><name sortKey="Lhomme, Catherine" sort="Lhomme, Catherine" uniqKey="Lhomme C" first="Catherine" last="Lhommé">Catherine Lhommé</name></country><country name="Canada"><noRegion><name sortKey="Provencher, Diane M" sort="Provencher, Diane M" uniqKey="Provencher D" first="Diane M" last="Provencher">Diane M. Provencher</name></noRegion><name sortKey="Oza, Amit M" sort="Oza, Amit M" uniqKey="Oza A" first="Amit M" last="Oza">Amit M. Oza</name></country><country name="Australie"><noRegion><name sortKey="Richardson, Gary" sort="Richardson, Gary" uniqKey="Richardson G" first="Gary" last="Richardson">Gary Richardson</name></noRegion></country><country name="Mexique"><noRegion><name sortKey="Rinc N, Dolores Gallardo" sort="Rinc N, Dolores Gallardo" uniqKey="Rinc N D" first="Dolores Gallardo" last="Rinc N">Dolores Gallardo Rinc N</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Marth, Christian" sort="Marth, Christian" uniqKey="Marth C" first="Christian" last="Marth">Christian Marth</name></noRegion></country><country name="Lettonie"><noRegion><name sortKey="Brize, Arija" sort="Brize, Arija" uniqKey="Brize A" first="Arija" last="Brize">Arija Brize</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Bamias, Aristotelis" sort="Bamias, Aristotelis" uniqKey="Bamias A" first="Aristotelis" last="Bamias">Aristotelis Bamias</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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